Omni 1000
Delivering deep biological insight with absolute quantification across 1,000 judiciously selected proteins — balancing comprehensive pathway coverage, clinical relevance, and discovery-ready utility.
Broad Coverage, Real-World Utility
Percentage of most valuable proteins (MVPs) captured on Omni, curated from top literature, mid-plex panels, endpoint assays, and pharma-preferred pathways to maximize relevance for discovery and development.
Reflects the percentage of top-level biological systems captured on Omni, ensuring full representation across foundational cellular and physiological processes as defined by Reactome’s highest organizational tier.
Represents the proportion of detailed functional pathways covered within each top-level system. This metric captures the depth of Omni’s biological breadth, mapping into specific molecular cascades and processes across human biology.
Tracks Omni’s ability to cover protein markers across all MeSH disease categories, ensuring broad utility for disease biology by aligning with the standard NIH classification of human health conditions.
Measures Omni’s coverage of the 46 most studied KEGG pathways, prioritized based on pharmaceutical pipeline activity, enabling high relevance to drug discovery and translational research across therapeutic areas.
Benchmarked against UK Biobank data, this metric reflects how much of the disease-predictive signal from a large 3,000-protein panel is retained by Omni’s overlapping 800-protein subset.
of Most Valuable Proteins
Level 0 Reactome Coverage
Level 1 reactome coverage
MSH Disease Classes
KEGG Drug Discovery Pathways
Disease Prediction Power
How we selected the most informative 1000 proteins
The Omni 1000 panel was designed through a two-pronged strategy. We first curated the Most Valuable Proteins — well-established biomarkers with proven utility across drug discovery and translational research. Second, we used a data-driven approach — applying machine learning and optimization methods on public high-plex proteomic datasets. The result was 1000 proteins that maximize biological coverage and recapitulate patient phenotypic information, all while minimizing redundancy.
Nomic Omni 1000 Target Library
Explore the list of Omni protein targets.
Download the full target list
Omni 1000 Validation Package
